Type VIII collagen has a restricted distribution in specialized extracellular matrices.
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منابع مشابه
Type VIII collagen has a restricted distribution in specialized extracellular matrices
A pepsin-resistant triple helical domain (chain 50,000 Mr) of type VIII collagen was isolated from bovine corneal Descemet's membrane and used as an immunogen for the production of mAbs. An antibody was selected for biochemical and tissue immunofluorescence studies which reacted both with Descemet's membrane and with type VIII collagen 50,000-Mr polypeptides by competition ELISA and immunoblott...
متن کاملTissue distribution of type VIII collagen in human adult and fetal eyes.
The type VIII collagen tissue distribution in human adult (32-78 yr of age) and fetal (16-27 weeks of gestation) eyes was studied immunohistochemically using a monoclonal antibody to type VIII collagen. Type VIII collagen was distributed in a linear or fibrous fashion in adult eyes in Descemet's membrane of the cornea, the trabecular meshwork, the walls of Schlemm's canal, Bruch's membrane, the...
متن کاملCholesterol-induced changes of type VIII collagen expression and distribution in carotid arteries of rabbit.
Lipoproteins play a major role in cardiovascular disease and atherosclerosis. In the vascular wall, they strongly influence the organization of extracellular matrix. The present study set out to investigate the changes in the extracellular matrix of the vessel wall induced by atherogenic diet, focusing on type VIII collagen, a vascular collagen that has not previously been investigated in detai...
متن کاملType XII collagen contributes to diversities in human corneal and limbal extracellular matrices.
PURPOSE To characterize diversities in the extracelhtlar matrices (ECMs) of the corneal and the surrounding limbal epithelium and stroma. METHODS Immunohistochemical analyses were employed for screening monoclonal antibodies (mAbs) developed against ECM components of the human corneal epithelial basement membrane (BM) zone. In the current study, mAb BM8 was used as the monospecific probe to c...
متن کاملLack of Type VIII Collagen in Mice Ameliorates Diabetic Nephropathy
OBJECTIVE Key features of diabetic nephropathy include the accumulation of extracellular matrix proteins. In recent studies, increased expression of type VIII collagen in the glomeruli and tubulointerstitium of diabetic kidneys has been noted. The objectives of this study were to assess whether type VIII collagen affects the development of diabetic nephropathy and to determine type VIII collage...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1988
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.107.2.721